Tetrabutylammonium Fluoride → 3-(4-Chloro-phenyl)-6-ethynyl-pyridazine

HRID 271704ノート

反応式

HRID 271704 の反応式
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[C:33][Si](C)(C)C)=[CH:30][CH:31]=2)=[CH:22][CH:21]=1>C(Cl)Cl>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[CH:33])=[CH:30][CH:31]=2)=[CH:24][CH:25]=1

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 673622923-(4-Chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine

生成物 1

HCID 859696873-(4-Chloro-phenyl)-6-ethynyl-pyridazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.10 g (3.49 mmol) TBAF are added at 0° C. to a solution of 1.00 g (3.49 mmol) 3-(4-chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine in 10 mL DCM. The ice bath is removed and the reaction solution is stirred for 30 min. Water is added and the aqueous phase is extracted with EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The product is reacted without any further purification.

後処理

  1. customThe ice bath is removed
  2. additionWater is added
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe organic phase is dried over MgSO4
  5. customThe product is reacted without any further purification

出典と根拠

ORDレコード
ord-d6e5ce41cbd94d4b817f088f7df52584
出典データセット
uspto-grants-2008_11
特許番号
US07452911B2

反応ノート

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