Stannous Chloride → 2-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

HRID 271707ノート

反応式

HRID 271707 の反応式
[Br:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:4][N:3]=1.[Sn](Cl)Cl.C([O-])(O)=O.[Na+]>CCOC(C)=O>[Br:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 24479Stannous ChlorideHCID 516892Sodium BicarbonateHCID 859696992-Bromo-5-(4-chlorophenyl)-3-nitropyridine

生成物 1

HCID 859697042-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 5.60 g (17.9 mmol) 2-bromo-5-(4-chloro-phenyl)-3-nitro-pyridine, 20.3 g (90.0 mmol) tin(II)-chloride and 18.9 g (225 mmol) NaHCO3 in 300 mL EtOAc is refluxed for 30 h. After filtration the solvent is eliminated i.vac. The residue is triturated with DCM and after filtration the filter residue is dried in the air.

後処理

  1. filtrationAfter filtration the solvent
  2. customThe residue is triturated with DCM
  3. filtrationafter filtration the filter residue
  4. customis dried in the air

出典と根拠

ORDレコード
ord-42d186145eb540ad80ecea9f5e9ad76f
出典データセット
uspto-grants-2008_11
特許番号
US07452911B2

反応ノート

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