ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Acetyl chloride → N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-acetoxy-5-oxo-2,5-dihydropyrrole

HRID 27186
ノート
印刷プレビュー

反応式

HRID 27186 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]2[OH:17])[CH:5]=[CH:6][C:7]=1[Cl:8].C([O-])([O-])=O.[K+].[K+].[C:24](Cl)(=[O:26])[CH3:25]>C(C(C)=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:10](=[O:17])[C:11]([CH3:16])=[C:12]([CH3:15])[CH:13]2[O:14][C:24](=[O:26])[CH3:25])[CH:5]=[CH:6][C:7]=1[Cl:8]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 13069714N-(3',4'-Dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole

生成物 1

HCID 13069715N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-acetoxy-5-oxo-2,5-dihydropyrrole

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

27.2 g of N-(3',4'-dichlorophenyl-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole (see Example 3) is refluxed together with 20.7 g of K2CO3 in 150 ml of methyl ethyl ketone. After cooling, there is added dropwise 8.2 g of acetyl chloride, with the temperature of the reaction mixture rising from 15° to 35°. The reaction mixture is filtered after 24 hours, and the filtrate is concentrated by evaporation. The residue is recrystallised from methanol to give 23.9 g (76% of theory) of the above product in the form of colourless crystals, m.p. 109°-110°.

後処理

  1. temperatureAfter cooling
  2. customrising from 15° to 35°
  3. filtrationThe reaction mixture is filtered after 24 hours
  4. concentrationthe filtrate is concentrated by evaporation
  5. customThe residue is recrystallised from methanol
  6. customto give 23.9 g (76% of theory) of the above product in the form of colourless crystals, m.p. 109°-110°

出典と根拠

ORDレコード
ord-452dc41dcc754181b5054dc81acc403b
出典データセット
uspto-grants-1980_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04220655

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート