2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine

HRID 271885

反応式

HRID 271885 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1>CO.C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1

参加物

3

反応物 1

HCID 38524282-Amino-6-methoxy-3-nitropyridine

生成物 1

HCID 30239202,3-Diamino-6-methoxypyridine

試薬・触媒・溶媒 1

HCID 18681192Ethanol, mixt. with methanol溶媒

実験手順

2-Amino-6-methoxy-3-nitropyridine (2.8 g, 16.5 mmol) was dissolved in warm 1:1 methanol/ethanol (200 mL). The solution was cooled, purged with argon, and 10% palladium on carbon was added (0.45 g). Hydrogen was introduced (1 atm) and the reaction stirred until complete. The catalyst was filtered and the solvent evaporated from the filtrate to give the title compound. MS 140 (M+1) 1H NMR (500 MHz, CDCl3) δ 6.93 (d, J=8 Hz, 1H), 6.04 (d, J=8 Hz, 1H), 4.15 (br s, 2H), 3.80 (s, 3H), 3.0 (br s, 2H).

後処理

  1. temperatureThe solution was cooled
  2. custompurged with argon, and 10% palladium on carbon
  3. additionwas added (0.45 g)
  4. additionHydrogen was introduced (1 atm)
  5. filtrationThe catalyst was filtered
  6. customthe solvent evaporated from the filtrate

出典と根拠

ORDレコード
ord-2e4f46fc488443e19b00066e91b15bb3
出典データセット
uspto-grants-2008_11
特許番号
US07452903B2

関連ノート

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