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Trifluoroacetic acid → Trifluoroacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate | HCID 22293253 | — |
| 生成物 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 2(1H)-Pyrimidinone | HCID 68401 | — |
反応手順
tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (0.10 g, 0.21 mmol) was dissolved in trifluoroacetic acid (5 mL) and stirred overnight. The reaction was concentrated to afford the bis-TFA salt of the title compound (0.048 g). MS 233.2 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07452903B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-93766037067847f196c43d97405c4735 |
| 出典メモ | uspto-grants-2008_11 |