Isopropyl Acetate → (2R)-2-(hydroxymethyl)hexanoic Acid
反応式
C[C@@H]([NH3+])C1C=CC=CC=1.[CH2:10]([C@H:14]([CH2:18][OH:19])[C:15]([O-:17])=[O:16])[CH2:11][CH2:12][CH3:13].C(OC(C)C)(=O)C>Cl>[CH2:10]([C@H:14]([CH2:18][OH:19])[C:15]([OH:17])=[O:16])[CH2:11][CH2:12][CH3:13]参加物
4
実験手順
(R)-2-Butyl-3-hydroxypropionic acid (R)-α-methylbenzylammonium salt (5, 10.0 g) is dissolved in 2 N HCl (40.0 mL) and isopropyl acetate (50.0 mL) is added to the mixture. After mixing for 5 min, the organic layer is separated and the aqueous layer is extracted with isopropyl acetate (3×50.0 mL). The combined organic layers are washed with water (20.0 mL) and concentrated under vacuum (20 mbar) until no further solvent distills to afford (R)-2-butyl-3-hydroxypropionic acid (1, 5.4 g, 98%); oil; [α]D+6.5 (c=1.0, CH3OH), (R):(S)=99.3:0.7.
後処理
- additionAfter mixing for 5 min
- customthe organic layer is separated
- extractionthe aqueous layer is extracted with isopropyl acetate (3×50.0 mL)
- washThe combined organic layers are washed with water (20.0 mL)
- concentrationconcentrated under vacuum (20 mbar) until no further solvent
- distillationdistills
出典と根拠
- ORDレコード
- ord-9645ef5267364df880496af826ae6058
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07452999B2
反応ノート
読み込み中…