Cyclohexyl methyl ketone → (2R)-N-({(3S)-1-(1-cyclohexylethyl)-3-piperidyl}methyl)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide

HRID 272088

反応式

HRID 272088 の反応式
[OH:1][C@H:2]1[CH2:6][N:5]([C:7](=[O:28])[CH2:8][C:9]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C@H:4]([C:29]([N:31]2[CH2:35][CH2:34][CH2:33][C@@H:32]2[C:36]([NH:38][CH2:39][C@@H:40]2[CH2:45][CH2:44][CH2:43][NH:42][CH2:41]2)=[O:37])=[O:30])[CH2:3]1.[CH3:46][C:47]([CH:49]1[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1)=O>>[CH:49]1([CH:47]([N:42]2[CH2:43][CH2:44][CH2:45][C@@H:40]([CH2:39][NH:38][C:36]([C@H:32]3[CH2:33][CH2:34][CH2:35][N:31]3[C:29]([C@@H:4]3[CH2:3][C@@H:2]([OH:1])[CH2:6][N:5]3[C:7](=[O:28])[CH2:8][C:9]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:30])=[O:37])[CH2:41]2)[CH3:46])[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1

参加物

3

反応物 2

HCID 13207Cyclohexyl methyl ketoneHCID 16086004(2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidine-2-yl]carbonyl-N-((3R)-3-piperidinylmethyl)pyrrolidine-2-carboxamide

生成物 1

HCID 69100804(2R)-N-({(3S)-1-(1-cyclohexylethyl)-3-piperidyl}methyl)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide

実験手順

The title compound was prepared by a method similar to Step 3 of Example 17, using (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-((3R) -3-piperidyl-methyl)pyrrolidine-2-carboxamide and cyclohexyl methyl ketone. The compound was obtained as a white solid.

後処理

  1. customThe compound was obtained as a white solid

出典と根拠

ORDレコード
ord-55c9e4e6d6f6409282fed8afdf288a0f
出典データセット
uspto-grants-2008_11
特許番号
US07452908B2

関連ノート

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