tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylate → (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-(3-pyrrolidylmethyl)pyrrolidine-2-carboxamide

HRID 272093

反応式

HRID 272093 の反応式
[NH2:1][CH2:2][CH:3]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.OCC1CCN(CC2C=CC=CC=2)C1.C([O:33][C@H:34]1[CH2:38][N:37]([C:39](=[O:60])[CH2:40][C:41]([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C@H:36]([C:61]([N:63]2[CH2:67][CH2:66][CH2:65][C@@H:64]2[C:68](O)=[O:69])=[O:62])[CH2:35]1)(C)(C)C>>[OH:33][C@H:34]1[CH2:38][N:37]([C:39](=[O:60])[CH2:40][C:41]([C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=2)([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)[C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)[C@H:36]([C:61]([N:63]2[CH2:67][CH2:66][CH2:65][C@@H:64]2[C:68]([NH:1][CH2:2][CH:3]2[CH2:7][CH2:6][NH:5][CH2:4]2)=[O:69])=[O:62])[CH2:35]1

参加物

4

反応物 3

HCID 2756485tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylateHCID 5176654(1-Benzylpyrrolidin-3-yl)methanolHCID 69100730(2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid

生成物 1

HCID 69101451(2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-(3-pyrrolidylmethyl)pyrrolidine-2-carboxamide

実験手順

The title compound was prepared by successively conducting procedures similar to Step 5 of Example 1 and Example 46, using 3-aminomethyl-1-(t-butoxycarbonyl)pyrrolidine [which was synthesized by a method similar to the one described in Japan Kokai Hei 11(1999)-193232, using 3-hydroxymethyl-1-benzylpyrrolidine [taught in Japan Kokai (laid-open) Hei 4(1992)-112868]] and (2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-pyrrolidine-2-carboxylic acid.

後処理

  1. customwas synthesized by a method similar to the one

出典と根拠

ORDレコード
ord-53c8a84da2ae4114ac29d94e0f3e327c
出典データセット
uspto-grants-2008_11
特許番号
US07452908B2

関連ノート

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