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Hydrochloric Acid → 3-(3-Methoxyphenyl)-2-oxopropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetylglycine | HCID 10972 | — |
| 反応物 | 3-Methoxybenzaldehyde | HCID 11569 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | 3-(3-Methoxyphenyl)-2-oxopropanoic acid | HCID 290091 | 34.1% |
反応手順
m-Anisaldehyde (25.9 g), N-acetylglycine (15.2 g) and sodium acetate (7.8 g) were heated together under reflux in acetic anhydride (50 ml) for 3/4 hour. The mixture was allowed to cool, water (150 ml) was added and the mixture was filtered to give the crude azlactone (27.7 g) m.p. 145°-150°. Hydrolysis with boiling 1 N hydrochloric acid (450 ml) followed by cooling and ether extraction afforded 3-methoxyphenylpyruvic acid as a pale yellow oily solid (6.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220767 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-0d710401d4e548719286207680e38f38 |
| 出典メモ | uspto-grants-1980_09 |