Butanal → HCID 70588461、化合物

反応式

[CH:1](=O)[CH2:2][CH2:3][CH3:4].[CH:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.S([O-])([O-])(=O)=O.[Na+].[Na+]>>[CH:1](=[C:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[NH2:12])[CH2:2][CH2:3][CH3:4]

参加物

反応物 3

HCID 261Butanal2 回

HCID 7965Cyclohexylamine2 回

HCID 24436Sodium Sulfate

生成物 1

HCID 70588461HCID 70588461、化合物収率 86%

実験手順

At 0° C., 16.3 g (20 mL, 0.23 mol) of butyraldehyde (Formula IV) was added dropwise to 21.7 g (25 mL, 0.22 mol) of cyclohexylamine (Formula III). After 1 h, 6 g of anhydrous sodium sulfate was added and the mixture stirred for 5 h. The product was decanted from the salt water slurry, dried by addition of further 10 g of anhydrous sodium sulfate, filtered and distilled. Characteristics of the product: bp 88° C. (20 mm); yield 86%; NMR (CDCl3, δ): 1.0 (3H, t) 1.1-2.1 (12H), 2.3 (2H, g), 3.0 (1H, m), 7.8 (1H, t).

後処理

customThe product was decanted from the salt water slurry
dry with materialdried by addition of further 10 g of anhydrous sodium sulfate
filtrationfiltered
distillationdistilled

出典と根拠

ORDレコード: ord-5176bc7b717446ac88b809a2854aef31
出典データセット: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04220774

反応ノート

読み込み中…

参加物