Acetyl chloride → 2-Acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline

HRID 27248ノート

反応式

HRID 27248 の反応式
[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:16]=2[CH2:15][NH:14][CH2:13][CH2:12]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:24](Cl)(=[O:26])[CH3:25]>C(Cl)Cl>[C:24]([N:14]1[CH2:13][CH2:12][C:11]2[C:16](=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:8]=[CH:9][CH:10]=2)[CH2:15]1)(=[O:26])[CH3:25]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 504718-Phenyl-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 233443892-Acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 4.2 parts of 8-phenyl-1,2,3,4-tetrahydroisoquinoline and 4 parts of triethylamine in 90 parts by volume of methylene chloride is cooled in an ice bath with stirring and 1.7 part of acetyl chloride in 10 parts by volume of methylene chloride is added slowly. The mixture is allowed to warm to ambient temperature and stirred for about 2 hours. The reaction solution is washed four times with 20 parts by volume portions of water and then dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to afford 2-acetyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline.

後処理

  1. stirringstirred for about 2 hours
  2. washThe reaction solution is washed four times with 20 parts by volume portions of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-bd168fbdeedf4c7582465d488dfca42c
出典データセット
uspto-grants-1980_09
特許番号
US04220778

反応ノート

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