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Dicyanamide → 2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyanamide | HCID 10443 | — |
| 反応物 | 3-Bromopropionitrile | HCID 17020 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | (1-(2-Pyridinylmethyl)-15-pyrrolidin-1-yl)acetonitrile benzenesulfonate | HCID 5458873 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine | HCID 23344422 | — |
反応手順
1-cyanomethyl-1-(2-picolyl)pyrrolidinium benzenesulfonate (see Preparation II) is rearranged and alkylated with 3-bromopropionitrile as in Example 2. The resulting dicyanoamine is decyanated with sodium borohydride in ethanol to give the product. Purification is effected via the picrate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220781 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-77ed0ada2d654ca3bda0d891202c6bc6 |
| 出典メモ | uspto-grants-1980_09 |