関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,3-Propanediamine | HCID 428 | — |
| 反応物 | 4-Methyl-2-[2-(2-nitrophenyl)diazenyl]phenol | HCID 74029 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Drometrizole | HCID 17113 | 64% |
反応手順
11.6 g of 1,3-diaminopropane (0.16 mol) and 2.62 g of Cu-II-acetylacetonate are placed into 100 ml of dimethylformamide, and the whole is heated in an inert atmosphere to 100° C. A solution of 10 g of 2-nitro-2'-hydroxy-5'-methyl-azobenzene in 50 ml of dimethylformamide is then added, and after 3 hours the reaction is finished. The conversion to 2-(2'-hydroxy-5'-methylphenyl)-benzotriazole gives a yield of 64%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04220788 |
|---|
| 出典データセット | uspto-grants-1980_09 |
|---|
| ORD ID | ord-f631accc4e7b40a2a3bc39ea3001a972 |
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| 出典メモ | uspto-grants-1980_09 |
|---|
