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Methanol → Methyl 3-bromo-2-pyridinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 3-Bromopyridine-2-carboxylic Acid | HCID 2050129 | — |
| 生成物 | Methyl 3-bromo-2-pyridinecarboxylate | HCID 12828946 | 42% |
反応手順
A mixture of 5.45 g of 3-bromo-2-pyridine carboxylic acid (27.0 mmol, 1 eq.), obtained in example 3b), in 100 ml of methanol is reflux heated in the presence of 8 ml of sulfuric acid. The reaction mixture is allowed to return to ambient temperature and poured into water. It is extracted 3 times with ethyl acetate, the organic phase is dried on Na2SO4 and vacuum evaporated. 2.48 g (42%) of esterified product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456192B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-eca464055933479c9ffeff3ae11eeeaa |
| 出典メモ | uspto-grants-2008_11 |