関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Ethyl 2-pyridylacetate | HCID 75960 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 3-(dimethylamino)-2-(2-pyridinyl)-2-propenoate | HCID 73047442 | — |
反応手順
10 g of ethyl 2-(2-pyridinyl)acetate, 39 ml of dimethoxy-N,N-dimethylmethanamine and 1.5 ml of N,N,N′,N′-tetramethylenediamine are mixed and the mixture is heated at 130° C. for 18 hours. The mixture is taken up in 120 ml of a mixture of equal volumes of AcOEt and of a saturated NH4Cl solution. The organic phase is separated by settling, washed with a saturated NaCl solution, dried over Na2SO4 and evaporated to produce the expected product in the form of an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07456193B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
|---|
| ORD ID | ord-ec53e341ddaf4945860d0989276badfa |
|---|
| 出典メモ | uspto-grants-2008_11 |
|---|
