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Trifluoroacetic acid → 2-(4-Aminopyridin-3-YL)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | tert-butyl N-[3-(2-hydroxyethyl)pyridin-4-yl]carbamate | HCID 11031933 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(4-Aminopyridin-3-YL)ethanol | HCID 45079443 | 40% |
反応手順
A solution of [3-(2-hydroxy-ethyl)-pyridin-4-yl]-carbamic acid tert-butyl ester (91 mg, 0.38 mmol) in CH2Cl2 (3 mL) was treated with TFA (2 mL) and stirred at room temperature for 3 hours. Concentrated under vacuum to provide 21 mg (23%) of desired product. MS (DCI) m/e 139 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456169B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-36b084094e9d4f2f8d190046e6a6dcfb |
| 出典メモ | uspto-grants-2008_11 |