Bromine → 5-Nitro-2-thenoic acid

反応式

[N+:1]([C:4]1[S:8][C:7]([CH:9]=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].BrBr.C(O)(=[O:15])C.C([O-])(=O)C.[Na+]>>[N+:1]([C:4]1[S:8][C:7]([C:9]([OH:15])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

反応物 3

HCID 24408Bromine

HCID 782815-Nitrothiophene-2-carboxaldehyde

HCID 23662384Sodium Diacetate

生成物 1

HCID 805915-Nitro-2-thenoic acid収率 98.5%

実験手順

As an example, a trial performed with 5-nitro-2-formyl-thiophene and bromine in a medium maintained at pH=4.6 by means of a acetic acid/sodium acetate mixture provided crude 5-nitro-2-thenoic acid in a yield of 98.5% or the pure acid in a yield of 81%.

出典と根拠

ORDレコード: ord-42320d16ee884924a0f49a03540d26f2
出典データセット: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04220793

反応ノート

読み込み中…