化工社化工社 化学情報印刷レポート · 研究参考用
5-Nitrothiophene-2-carboxaldehyde → 5-Nitro-2-thenoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Nitrothiophene-2-carboxaldehyde | HCID 78281 | — |
| 反応物 | Hypobromite | HCID 5460626 | — |
| 反応物 | Hypoiodite | HCID 5460636 | — |
| 反応物 | Sodium Hypochlorite | HCID 23665760 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 5-Nitro-2-thenoic acid | HCID 80591 | 75% |
反応手順
It has also been observed, in accordance with another aspect of the present invention, that a mixture of halogen and alkali metal hydroxide i.e. an alkali metal hypohalide such as sodium hypochlorite, hypobromite or hypoiodite when it is added to an aqueous suspension of 5-nitro-2-formyl-thiophene maintained at a pH between 4.5 and 6.5 by means of acetic acid or an acetic acid/alkali metal acetate mixture, provides pure 5-nitro-2-thenoic acid in a yield of at least 75%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220793 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-81d77bcf0ad94a3c84a882a64c8d8882 |
| 出典メモ | uspto-grants-1980_09 |