化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Iodide → 4-[4-(methylthio)phenyl]tetrahydro-2H-pyran-4-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Bis(2-bromoethyl) ether | HCID 21521 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-(4-(Methylthio)phenyl)acetonitrile | HCID 2760087 | — |
| 生成物 | 4-[4-(methylthio)phenyl]tetrahydro-2H-pyran-4-carbonitrile | HCID 68576613 | 77% |
反応手順
The title compound (5.5 g, 77%, solid after trituration in pentane) was prepared using 4-(methylthio)phenylacetonitrile, bis(2-bromoethyl)ether, sodium hydride and potassium iodide similarly to the procedure used for intermediate 56. Microanalysis: Found: C, 66.62; H, 6.46; N, 5.97%. C13H15NOS requires C, 66.92; H, 6.48; N, 6.00%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456164B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-d5f7c07a194b453e8a04f9ba24e4bd52 |
| 出典メモ | uspto-grants-2008_11 |