Oct-7-en-1-ol → 7-Octenoic acid

HRID 27309

反応式

HRID 27309 の反応式
[CH2:1]([OH:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]=[CH2:8].CC(C)=[O:12].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[C:1]([OH:12])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]=[CH2:8]

参加物

4

反応物 2

HCID 83203Oct-7-en-1-olHCID 131709961Jones' reagent

生成物 1

HCID 5439777-Octenoic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirred solution of 152 g of oct-7-en-1-ol (prepared in Example 22 B-1) in 3.4 liters of acetone there was added 1.4 M of Jones Reagent (986 ml) while the mixture was maintained at less than 10° C. The mixture was stirred for 10 min and was quenched with 100 ml of isopropanol. The acetone volume was reduced in vacuo and the residue was diluted with water and extracted three times with equal volumes of ethyl acetate. The combined ethyl acetate extracts were washed two times with water, then with saturated aqueous sodium chloride, dried over magnesium sulfate and evaporated in vacuo to yield 164 g of the title compound having the following physical characteristics:

後処理

  1. temperaturewas maintained at less than 10° C
  2. customwas quenched with 100 ml of isopropanol
  3. additionthe residue was diluted with water
  4. extractionextracted three times with equal volumes of ethyl acetate
  5. washThe combined ethyl acetate extracts were washed two times with water
  6. dry with materialwith saturated aqueous sodium chloride, dried over magnesium sulfate
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-97d0545d1cd34b9688c44edac3779056
出典データセット
uspto-grants-1980_09
特許番号
US04220795

関連ノート

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