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Hydrazine hydrate (1:1) → 3-Cyanobenzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Benzoic acid, 3-cyano-, methyl ester | HCID 83554 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-Cyanobenzohydrazide | HCID 21942658 | 52.7% |
反応手順
A mixture of 3-cyano-benzoic acid methyl ester (2 g, 12 mmol) and hydrazine monohydrate (0.60 mL, 12 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and then the residue was triturated with diethyl ether to afford 3-cyano-benzoic acid hydrazide (1.02 g, 51%, pink solid). 1H NMR (DMSO) δ (ppm): 10.31 (s, 1H), 8.21 (m, 1H), 8.11 (m, 1H), 7.99 (m, 1H), 7.70 (m, 1H), 4.50 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456200B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-da855c96036c4c68ad18d2cc8a681244 |
| 出典メモ | uspto-grants-2008_11 |