関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Potassium Nitrate | HCID 24434 | — |
| 反応物 | 3-Fluorobenzonitrile | HCID 67880 | — |
| 生成物 | 5-Fluoro-2-nitrobenzonitrile | HCID 3756467 | 86.5% |
反応手順
m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3°-6° C., then allowed to warm to 25° C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5×250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102°-104° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04220468 |
|---|
| 出典データセット | uspto-grants-1980_09 |
|---|
| ORD ID | ord-cb1735812ec4484a8d1e4df1f958a039 |
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| 出典メモ | uspto-grants-1980_09 |
|---|
