Ethyl 3-(nitromethyl)heptanoate → 4-Butylpyrrolidin-2-one
反応式
C([O:3][C:4](=O)[CH2:5][CH:6]([CH2:11][N+:12]([O-])=O)[CH2:7][CH2:8][CH2:9][CH3:10])C.[H][H]>CO.[Ni]>[CH2:7]([CH:6]1[CH2:11][NH:12][C:4](=[O:3])[CH2:5]1)[CH2:8][CH2:9][CH3:10]参加物
5
実験手順
To a solution of 3-nitromethylheptanoic acid ethyl ester (10 g, 49.2 mmol) in methanol (100 mL) under argon was added Raney Ni (5 g). The mixture was stirred under 50 psi of hydrogen for 48 h, flushed with argon, filtered through a Celite pad, and concentrated under vacuum to afford 4-butylpyrrolidin-2-one as a colorless oil (6.3 g, 91%). MS(ES) m/e 142 [M+H]+.
後処理
- customflushed with argon
- filtrationfiltered through a Celite pad
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-374e99d513034b30adb95a0386b6fa3f
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456211B2
反応ノート
読み込み中…