関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (3,5-Dimethoxyphenyl)acetic acid | HCID 138316 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-(3,5-Dimethoxyphenyl)ethanol | HCID 265634 | 103.2% |
反応手順
To a mixture of LiAlH4 (1.05 g) in dioxane (100 ml) was added a solution of 3,5-dimethoxyphenyl acetic acid (5.32 g) in dioxane (20 ml) portionwise at 0° C. The mixture was stirred at room temperature for 0.5 hour and at 50° C. for 2 hours. The mixture was quenched with conc. NH4OH and filtered through Celite. The filtrate was evaporated to yield 3,5-dimethoxyphenethyl alcohol (5.1 g). IR (Neat) 3400, 1600 cm−1; MS (GC−EI) 182 (M+), 151 (M—MeO).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07456217B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
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| ORD ID | ord-98fc9dd307094083928613de837213f1 |
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| 出典メモ | uspto-grants-2008_11 |
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