Potassium Carbonate → HCID 178515692、化合物
反応式
C([O:4][C:5]1[N:10]=[C:9]2[N:11](C(=O)C)[CH:12]=[CH:13][C:8]2=[CH:7][CH:6]=1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO.O>[NH:11]1[C:9]2=[N:10][C:5]([OH:4])=[CH:6][CH:7]=[C:8]2[CH:13]=[CH:12]1参加物
4
実験手順
A mixture of 1-acetyl-1H-pyrrolo[2,3-b]pyridin-6-yl acetate (0.635 g, 2.9 mmol) and K2CO3 (1.6 g, 12 mmol) in MeOH/H2O (20 mL/20 mL) was stirred at room temperature for 12 h. The reaction mixture was concentrated to half its volume and extracted with CHCl3. The organic layer was dried over anhydrous MgSO4 and evaporated to give a residue, which was further purified on a silica gel column to give 1H-pyrrolo[2,3-b]pyridin-6-ol (0.233 g, 60%).
後処理
- concentrationThe reaction mixture was concentrated to half its volume
- extractionextracted with CHCl3
- dry with materialThe organic layer was dried over anhydrous MgSO4
- customevaporated
- customto give a residue, which
- customwas further purified on a silica gel column
出典と根拠
- ORDレコード
- ord-3ffd5ab5378e441c9a9471e2fdedae68
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456289B2
反応ノート
読み込み中…