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Sodium hydride → 2-chloro-N-(isoxazol-3-yl)methyl-N-(2,6-dimethylphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Chloro-N-(2,6-dimethylphenyl)acetamide | HCID 70798 | — |
| 反応物 | 3-(Bromomethyl)-1,2-oxazole | HCID 10464616 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-chloro-N-(isoxazol-3-yl)methyl-N-(2,6-dimethylphenyl)acetamide | HCID 13037602 | — |
反応手順
A mixture of 6.1 g N-chloroacetyl-2,6-dimethylaniline and 5 g 3-bromomethylisoxazole (prepared as in Example 6 above) in 200 ml dry dimethylformamide was treated with 1.5 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield a pure product, m.p. 78°-81° C. This product is shown as Compound 2 in Table I. C14H15ClN2O2 : calc., %C 60.32, %H 5.39, %N 10.05; found, %C 60.72, %H 5.71, %N 8.85.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221584 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-865d1a1ecb8f4ee79b385fa61a1a521e |
| 出典メモ | uspto-grants-1980_09 |