反応式
O[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])C>CO>[F:8][C:6]1[CH:7]=[CH:2][C:3]([CH:9]=[O:11])=[CH:4][CH:5]=1参加物
3
実験手順
To a mixture of (2-hydroxy-4-fluoro phenyl)-1-ethanone (3 g, 19.7 mmol) obtained in Preparation 5, and 4-fluorobenzaldehyde (4.37 g, 19.7 mmol) in methanol was slowly added sodium hydroxide solution at 0° C., under N2 atm. The reaction mixture was allowed to stir for 10 hours at 0-10° C. Water (100 mL) was added to it followed by 6 N HCl (15 mL). Solid separated was filtered off and dried under vacuum to afford 3 g (41%) of the title compound as a yellow solid.
出典と根拠
- ORDレコード
- ord-882c3530be6e4406ac9e528337db66ac
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456288B2
関連ノート
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