1,1'-Biphenyl, 4-(bromomethyl)- → N-([1,1'-biphenyl]-4-ylmethyl)-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

HRID 273583ノート

反応式

HRID 273583 の反応式
BrCc1ccc(-c2ccccc2)cc1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1>O=S(=O)(O)O.[Li]N([Si](C)(C)C)[Si](C)(C)C.CN(C)C=O.CN(C)C=O.CN(C)C=O.COCCOCCOC>CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(Cl)cc4)o3)cc2)CC1.O=C(c1ccc(-c2ccc(Cl)cc2)o1)N(Cc1ccc(-c2ccccc2)cc1)c1ccc(N2CCNCC2)cc1

参加物

8

反応物 2

HCID 2577161,1'-Biphenyl, 4-(bromomethyl)-HCID 168301698t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

生成物 2

HCID 168301698t-Butyl 4-(4-(5-(4-chlorophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate2 回HCID 168301702N-([1,1'-biphenyl]-4-ylmethyl)-5-(4-chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide収率 36%

試薬・触媒・溶媒 4

HCID 1118Sulfuric Acid試薬HCID 178418261HCID 178418261、化合物試薬HCID 6228Dimethylformamide溶媒3 回HCID 8150Diglyme溶媒

反応条件

温度
23 °C

後処理

  1. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  2. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  3. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  4. additionThe reactions were further diluted to 10 mM using DMSO.

出典と根拠

ORDレコード
ord-226d4aac36ad4899ae79cbd23037fd29
出典データセット
Cernak miniaturized N-alkylation with BOC deprotection
元リンク
出典を表示

反応ノート

読み込み中…