2-Amino-4-methylphenol → HCID 20094247、化合物

HRID 273741

反応式

HRID 273741 の反応式
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[CH:3]=1.[CH:10]([C:12]1[CH:21]=[CH:20][CH:19]=[CH:18][C:13]=1[C:14]([O:16][CH3:17])=[O:15])=O>C(O)C>[OH:8][C:7]1[CH:6]=[CH:5][C:4]([CH3:9])=[CH:3][C:2]=1[N:1]=[CH:10][C:12]1[CH:21]=[CH:20][CH:19]=[CH:18][C:13]=1[C:14]([O:16][CH3:17])=[O:15]

参加物

4

反応物 2

HCID 72642-Amino-4-methylphenolHCID 243003Methyl 2-formylbenzoate

生成物 1

HCID 20094247HCID 20094247、化合物収率 76.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-amino-p-cresol (7.4 g) and methyl 2-formylbenzoate (obtained as described in J. Chem. Soc. (C), 1969, 1818) (9.8 g) in ethanol (120 ml) was heated under reflux for 2 hours. The solvent was removed by evaporation and the residue recrystallised from hexane to give 2-hydroxy-5-methyl-N-(2-methoxycarbonylbenzylidene)aniline (B) (12.3 g), m.p. 82°-83° C; NMR: 2.35 (s, 3H), 4.0(s, 3H), 6.9(d, 1H), 7.0(d, 1H), 7.05(br s, 1H), 7.15(d, 1H), 7.5-7.7(m, 2H), 7.95(dd, 1H), 8.2(dd, 1H), 9.45(s, 1H).

後処理

  1. temperatureunder reflux for 2 hours
  2. customThe solvent was removed by evaporation
  3. customthe residue recrystallised from hexane

出典と根拠

ORDレコード
ord-2d1372c3c1144a0196cbf9f0a30d7900
出典データセット
uspto-grants-1995_02
特許番号
US05387592

関連ノート

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