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Sodium hydride → 2,2-Dimethyl-4-(6-hydroxy-3-pyridazinyloxy)-6-cyanochroman
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-bromo-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran | HCID 10244628 | — |
| 反応物 | pyridazine-3,6-diol | HCID 178516298 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2,2-Dimethyl-4-(6-hydroxy-3-pyridazinyloxy)-6-cyanochroman | HCID 178426770 | — |
反応手順
1.2 g of 80% NaH are added to a solution of 2.66 g of 2,2-dimethyl-4-bromo-6-cyanochroman (m.p. 89°-92°; obtainable by reduction of 2,2-dimethyl-6-cyano-4-chromanone with NaBH4, in CH3OH to give oily 2,2-dimethyl-6-cyano-4-chromanol and reaction with PBr3 in toluene at 20°) and 2.5 g of pyridazine-3,6-diol in 70 ml of DMSO and the mixture is stirred at 20° for 3 days. After customary working up, 2,2-dimethyl-4-(6-hydroxy-3-pyridazinyloxy)- 6-cyanochroman, m.p. 221°-224°, is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05387587 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-89e94ebffcf6417688bebde04fb45500 |
| 出典メモ | uspto-grants-1995_02 |