Ammonia → 4-fluoro-2-(1H-1,2,4-triazol-5-yl)aniline
反応式
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=C[N:6]3[N:12]=[CH:13][N:14]=[C:5]3[C:4]=2[CH:3]=1.N>Cl>[F:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:8])=[C:4]([C:5]2[N:14]=[CH:13][NH:12][N:6]=2)[CH:3]=1参加物
4
実験手順
4. 2.3 g of 9-fluoro-1,2,4-triazolo[1,5-c]quinazoline in 40 ml of 6N hydrochloric acid are stirred at 95° C. for 1 h. and then cooled in an ice bath. The reaction solution is poured into 30 ml of 25% aqueous ammonia and stirred in an ice bath for 10 min. The crystals are filtered off, washed with 30 ml of ice-cold water and dried in a vacuum. 2.0 g of 4-fluoro-2-(1H-1,2,4-triazol-3-yl)aniline of m.p. 142.5°-144.5° C. are obtained.
後処理
- temperaturecooled in an ice bath
- filtrationThe crystals are filtered off
- washwashed with 30 ml of ice-cold water
- customdried in a vacuum
出典と根拠
- ORDレコード
- ord-b4275a222296401a9bc3c819d8014df6
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387585
反応ノート
読み込み中…