HCID 20094336、化合物 → 1-[7-Amino-5-(2-bromopropyl)-2,3-dihydro-1H-indol-1-yl]ethanone
反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:16][CH:17]([Br:19])[CH3:18])=[CH:10][C:11]=2[N+:13]([O-])=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)C.[Pt]=O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:16][CH:17]([Br:19])[CH3:18])=[CH:10][C:11]=2[NH2:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]参加物
4
実験手順
To a solution of 1-acetyl-5-(2-bromopropyl)-7-nitroindoline (50 g) in ethanol (1.5 l) was added platinum oxide (2.5 g), and the mixture was stirred at room temperature for 4 hours under an atmosphere of hydrogen. After the catalyst was filtered off, the filtrate was evaporated under reduced pressure to give 45 g of 1-acetyl-7-amino-5-(2-bromopropyl)indoline.
後処理
- filtrationAfter the catalyst was filtered off
- customthe filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-ce3aee2519a342d4b2566056f985b12a
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387603
反応ノート
読み込み中…