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Formaldehyde → 2-(2-Hydroxy-3-diethylaminomethyl-5-methylphenyl)-2H-benzotriazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | Drometrizole | HCID 17113 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2-(2-Hydroxy-3-diethylaminomethyl-5-methylphenyl)-2H-benzotriazole | HCID 15919022 | — |
反応手順
2-(2-Hydroxy-5-methylphenyl)-2H-benzotriazole (74.3 g, 0.33 tool), diethylamine (37.0 g, 0.51 mol) and paraformaldehyde (17.1 g) are dissolved in 85 mL of n-butanol. The mixture is heated with agitation at reflux (95° to 100° C.) for 44 hours. The solvent is then removed by vacuum distillation to give a yellow viscous liquid as product in high yield (>99%). This Mannich base is identified as the above-named compound by thin layer chromatography using toluene as the mobile phase.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05387691 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-50be053378cd4aac916212eea72f6f37 |
| 出典メモ | uspto-grants-1995_02 |