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Ethylene Oxide → 3-(2-Hydroxyethyl)butyrolactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Oxide | HCID 6354 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | (Oxan-4-yl)methanol | HCID 2773573 | — |
| 生成物 | 3-(2-Hydroxyethyl)butyrolactone | HCID 9877372 | — |
| 生成物 | Ethyl oxane-4-carboxylate | HCID 13467581 | — |
反応手順
It is known that 4-hydroxymethyltetrahydropyran can be prepared in three steps: reaction of ethyl acetoacetate with ethylene oxide to form 3-(2-hydroxyethyl)gamma-butyrolactone (EP-A-246 581), rearrangement to ethyl tetrahydropyran-4-carboxylate (EP-A-284 969), and subsequent catalytic hydrogenation to form 4-hydroxymethyltetrahydropyran (DE-A-4 141 222).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05387701 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-482607a9bd004ff48a386bd144090d9e |
| 出典メモ | uspto-grants-1995_02 |