Eugenol → Methyl isoeugenol

反応式

C1(OC)C(=CC=C(C=1)CC=C)O.C1CCN2C(=NCCC2)CC1.C(=O)(OC)OC.[CH3:30][O:31][C:32]1[C:33]([O:41][CH3:42])=[CH:34][C:35]([CH2:38][CH:39]=[CH2:40])=[CH:36][CH:37]=1>>[CH3:30][O:31][C:32]1[C:33]([O:41][CH3:42])=[CH:34][C:35]([CH:38]=[CH:39][CH3:40])=[CH:36][CH:37]=1

参加物

反応物 4

HCID 3314Eugenol2 回

HCID 7127Methyleugenol

HCID 12021Dimethyl Carbonate

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

生成物 1

HCID 7128Methyl isoeugenol収率 86%

反応条件

温度: 150 °C

実験手順

15 mol of eugenol was charged into a pressure reactor, along with 0.2 mol of 1,8-diazabicyclo[5.4.0]-7-undecene and 16 mol of dimethyl carbonate. The reactor was sealed and was heated to 150° C. After 2 hr, complete conversion of the eugenol was shown to have occurred. After the distillation, 13 mol of eugenol methyl ether and 1 mol of isoeugenol methyl ether were obtained, corresponding to a yield of 86%, based on the starting amount of eugenol.