Phosphoric Acid → 4-Ketotridec-2-enoic acid

HRID 273945

反応式

HRID 273945 の反応式
[CH3:1][C:2](=[O:12])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].O.[C:14]([OH:18])(=[O:17])[CH:15]=O.P(=O)(O)(O)O>C(OCC)C.ClCCl>[O:12]=[C:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH:1]=[CH:15][C:14]([OH:18])=[O:17]

参加物

5

反応物 3

HCID 1004Phosphoric AcidHCID 81632-UndecanoneHCID 15620607Glyoxylic acid, monohydrate

生成物 1

HCID 540772154-Ketotridec-2-enoic acid

試薬・触媒・溶媒 1

HCID 21881112Ethyl ether methylene chloride溶媒

実験手順

A mixture of 2-undecanone (10 g, 58.7 mmol), glyoxylic acid monohydrate (5.15 g, 56 mmol) and 85% phosphoric acid (10 ml) was warmed at 80° for 18 hours. On cooling to room temperature, the mixture was diluted with ethyl ether/dichloromethane (50 ml each) and washed thoroughly with brine. Evaporation of the dried (magnesium sulphate) organic phase gave a yellow oil which on crystallization from ethyl ether/petroleum ether gave 4-ketotridec-2-enoic acid as colorless prisms.

後処理

  1. temperaturewas warmed at 80° for 18 hours
  2. washwashed thoroughly with brine
  3. customEvaporation of the
  4. dry with materialdried (magnesium sulphate) organic phase
  5. customgave a yellow oil which
  6. customon crystallization from ethyl ether/petroleum ether

出典と根拠

ORDレコード
ord-b680a318f6074a63be87de4db4853863
出典データセット
uspto-grants-1995_02
特許番号
US05387606

関連ノート

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