Ammonia → alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

HRID 27408ノート

反応式

HRID 27408 の反応式
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[NH3:13]>CO>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([NH2:13])=[O:1]

参加物

4

反応物 2

HCID 222AmmoniaHCID 23342878HCID 23342878、化合物

生成物 1

HCID 23342879alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

10.15 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 100 ml of methanol and the solution is saturated with ammonia, the temperature rising spontaneously to 40° C. The mixture is kept at that temperature for 30 minutes, whereupon it is allowed to return to ambient temperature. The reaction mixture is then evaporated under reduced pressure and the resulting powder is recrystallized from absolute ethanol. 10 g of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained. M.P.: 164°-165° C.; yield: 90% of theory.

後処理

  1. customrising spontaneously to 40° C
  2. customto return to ambient temperature
  3. customThe reaction mixture is then evaporated under reduced pressure
  4. customthe resulting powder is recrystallized from absolute ethanol

出典と根拠

ORDレコード
ord-3be00ad94a5d4ee49aaca088c2be7f15
出典データセット
uspto-grants-1980_09
特許番号
US04221789

反応ノート

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