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Phenylacetonitrile → 2-(alpha-Cyanobenzylidene)perhydroazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylacetonitrile | HCID 8794 | — |
| 反応物 | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| 反応物 | 1,5-Diazabicyclo(5,4,0)undec-5-ene | HCID 314112 | — |
| 生成物 | 2-(alpha-Cyanobenzylidene)perhydroazepine | HCID 70592161 | 41.7% |
反応手順
Stir 8.1 g of caprolactim methyl ether and 5.0 g of benzyl cyanide with 0.6 g of 1,5-diazabicyclo [5.4.0]undec-5-ene under nitrogen for 48 hours at 130°; distil off any excess benzyl cyanide under a high vacuum, and rub down the thus-produced residue with a little methyl alcohol before filtering to obtain 3.78 g of the title compound. Recrystallize from methyl alcohol to obtain a purer product, MP 108° to 113°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221788 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-c9465b3257644a528074cceea561fa4e |
| 出典メモ | uspto-grants-1980_09 |