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Triethylene Glycol → 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylene Glycol | HCID 8172 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-(4-Chlorobenzyl)-1-[3-(4-fluorobenzoyl)propyl]perhydroazepine | HCID 23342853 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine | HCID 23342834 | 62.2% |
反応手順
Heat 0.5 g of the title compound of Example 39 with 1 ml of hydrazine hydrate, 0.5 g of potassium hydroxide and 5 ml of triglycol for 2 hours at 165°. Cool the resulting reaction mixture to ambient temperature. Mix the cooled reaction mixture with water and diethyl ether. Dry the ether phase over sodium sulfate and then concentrate it to obtain 0.3 g of the title compound as a viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221788 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-263ae71c66374e658004a1b702d7a9d6 |
| 出典メモ | uspto-grants-1980_09 |