Hydrogen iodide → 9-(1-Hydroxy-2-propyl)-6-iodopurine

HRID 27443

反応式

HRID 27443 の反応式
[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2Cl)[CH3:4].[IH:15]>O>[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[I:15])[CH3:4]

参加物

4

反応物 2

HCID 24841Hydrogen iodideHCID 4540192-(6-Chloropurin-9-yl)propan-1-ol

生成物 1

HCID 233429069-(1-Hydroxy-2-propyl)-6-iodopurine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194° uv λmax 276 nm (H2O, pH 5.5).

後処理

  1. filtrationThe precipitate was filtered
  2. customneutralized with anhydrous sodium acetate at 5°
  3. washwashed with a little cold water (3 times)
  4. customRecrystallization from ethanol/H2O
  5. customgave colorless crystals

出典と根拠

ORDレコード
ord-9dfef0452a764a4b8d5f42cfbdf0f424
出典データセット
uspto-grants-1980_09
特許番号
US04221794

関連ノート

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