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1,3,4-Thiadiazol-2-amine → 5-(Imidazo-[2,1-b]-1,3,4-thiadiazol-6-yl)-3-nitropyrocatechol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| 反応物 | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 5-(Imidazo-[2,1-b]-1,3,4-thiadiazol-6-yl)-3-nitropyrocatechol | HCID 21459093 | — |
反応手順
A solution of 1.38 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 505.7 mg of 2-amino-1,3,4-thiadiazole in 25 ml of n-butanol is heated to boiling under reflux for 7 hours. The reaction mixture is then cooled to room temperature and the separated crystals are filtered under suction. There is obtained 5-(imidazo-[2,1-b]-1,3,4-thiadiazol-6-yl)-3-nitropyrocatechol of m.p. 278°-280° (from methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389653 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-6c05c0db42184ebc9d1e5bc9922b6e4f |
| 出典メモ | uspto-grants-1995_02 |