2-Aminothiazole → 5-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide

HRID 274470

反応式

HRID 274470 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[NH2:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1>C(O)C>[BrH:1].[S:18]1[CH:19]=[CH:20][N:21]2[CH:2]=[C:3]([C:5]3[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=3)[N:16]=[C:17]12

参加物

4

反応物 2

HCID 21552-AminothiazoleHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

生成物 1

HCID 214591435-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2.78 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone, 1.01 g of 2-aminothiazole and 40 ml of ethanol is heated to boiling under reflux for 23 hours. The reaction mixture is then cooled to room temperature and the crystals are removed by filtration under suction. There is obtained 5-(imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide of m.p. 286°-28820 (from methanol).

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 23 hours
  3. customthe crystals are removed by filtration under suction

出典と根拠

ORDレコード
ord-5e364a4d4d274bdaae63883439bcc2e6
出典データセット
uspto-grants-1995_02
特許番号
US05389653

関連ノート

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