化工社化工社 化学情報印刷レポート · 研究参考用
Benzo(d)thiazol-2-amine → 5-(Imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzo(d)thiazol-2-amine | HCID 8706 | — |
| 反応物 | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(Imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol | HCID 21459069 | — |
反応手順
A mixture of 1.95 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone, 1.06 g of 2-aminobenzothiazole and 50 ml of ethanol is heated to boiling under reflux for 17 hours. The reaction mixture is then cooled to room temperature, whereupon the crystals are removed by filtration under suction. There is obtained 5-(imidazo[2,1-b]benzothiazol-2-yl)-3-nitropyrocatechol of m.p. 303°-305° (from N,N-dimethylformamide/methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389653 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-c6b1a535c5ee4613b184f2f0f99a485a |
| 出典メモ | uspto-grants-1995_02 |