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Thionicotinamide → 3-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionicotinamide | HCID 737155 | — |
| 反応物 | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| 生成物 | 3-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol | HCID 21459199 | — |
反応手順
A suspension of 2.91 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 1.31 g of thionicotinamide in 50 ml of alcohol and heated to boiling under reflux for 2 hours. After cooling to room temperature the crystals are filtered under suction and recrystallized from N,N-dimethylformamide/alcohol. There is obtained 3-nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol of m.p. 279°-281°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389653 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-9e82f967678f416c958045fed731d3fa |
| 出典メモ | uspto-grants-1995_02 |