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(2-Fluoro-3,4-dimethoxyphenyl)methanol → 2-Fluoro-3,4-dimethoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Fluoro-3,4-dimethoxyphenyl)methanol | HCID 19838191 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-Fluoro-3,4-dimethoxybenzaldehyde | HCID 603588 | — |
反応手順
3.0 g of 2-fluoro-3,4-dimethoxybenzyl alcohol and 5.0 g of manganese dioxide are heated under reflux for 1 hour together with 50 ml of benzene. The insoluble constituents are subsequently filtered while washing with methylene chloride. The filtrate is evaporated and the residue is recrystallized from methylene chloride/hexane. There is obtained 2-fluoro-3,4-dimethoxybenzaldehyde of m.p. 52°-54°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389653 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-44d467d8839847ccb746f07fcfc1078d |
| 出典メモ | uspto-grants-1995_02 |