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N-bromobutanimide → 1H-Pyrrole-2-carbonitrile, 1-[4-(bromomethyl)phenyl]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 1-(4-Methylphenyl)pyrrole-2-carbonitrile | HCID 2797715 | — |
| 触媒 | Perbenzoic acid | HCID 523077 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 1H-Pyrrole-2-carbonitrile, 1-[4-(bromomethyl)phenyl]- | HCID 10332861 | 94% |
反応手順
A solution of 1-(4-methylphenyl)pyrrole-2-carbonitrile (4.9 g), N-bromosuccinimide (5.5 g) and perbenzoic acid (65 mg) in carbon tetrachloride was heated under reflux in light radiation for 2 hours. After removal of insoluble materials by filtration, the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford a colorless syrup (6.6 g, 93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389641 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-490f5ed6fd034cfc9f921723c0596a31 |
| 出典メモ | uspto-grants-1995_02 |