化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Benzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | m,alpha-Dichlorotoluene | HCID 12103 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(2-Acetamidoethyl)benzoic acid | HCID 343701 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 4-(2-Aminoethyl)-benzoic acid sodium | HCID 70590830 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Benzoic Acid | HCID 243 | — |
反応手順
50 ml of a 1-molar solution of 4-(2-aminoethyl)-benzoic acid-sodium, which contained, in addition, 0.05 mole of sodium acetate and which had been prepared by saponification of 4-(2-acetylaminoethyl)-benzoic acid with sodium hydroxide solution, was combined with 50 ml of acetone and then with the solution of 9 g of 3-chlorobenzyl chloride in a small amount of acetone. The whole was stirred for about 1 hour, water and hydrochloric acid were added, filtered off with suction and the product was recrystallized from a mixture of water and isopropanol. The 4-(2-<3-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 200° to 202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221815 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-9025e657a2784680af368ace6a1095ec |
| 出典メモ | uspto-grants-1980_09 |