Propionyl chloride → HCID 23343022、化合物

HRID 27472ノート

反応式

HRID 27472 の反応式
[C:1]([C:4]1[CH:22]=[CH:21][C:7]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[O:9])=[CH:6][CH:5]=1)([OH:3])=[O:2].[C:23](Cl)(=[O:26])[CH2:24][CH3:25]>C(O)(C)C>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([NH:20][C:23](=[O:26])[CH2:24][CH3:25])[CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[O:9])=[CH:21][CH:22]=1)([OH:3])=[O:2]

参加物

4

反応物 2

HCID 62324Propionyl chlorideHCID 233430382-(4-Carboxybenzamido)-4-aminobenzoic acid

生成物 1

HCID 23343022HCID 23343022、化合物収率 62%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

The procedure of Example 4 was repeated to react 2-(4-carboxybenzamido)-4-aminobenzoic acid with propionyl chloride, and the reaction product was treated as in Example 4 except that isopropyl alcohol was used as a solvent for recrystallization. The product obtained was a 62% yield of 2-(4-carboxybenzamido)-4-propionamidobenzoic acid having a melting point in the range of from 284° to 286° C. (decompose).

後処理

  1. customwas used as a solvent for recrystallization
  2. customThe product obtained

出典と根拠

ORDレコード
ord-47e35bb137994dbc9816a068225b13f4
出典データセット
uspto-grants-1980_09
特許番号
US04221814

反応ノート

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