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Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine Hydrochloride | HCID 9082 | — |
| 反応物 | 4-Methylimidazol-5-ylmethanolhydrochloride | HCID 3084707 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | 164.7% |
反応手順
A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04221802 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-9d4a886ceb724adbb862d5e6bfc3186b |
| 出典メモ | uspto-grants-1980_09 |