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Propylamine → 8-chloro-2-(N-n-propylamino)tetralin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propylamine | HCID 7852 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 8-Chloro-1,2,3,4-tetrahydronaphthalen-2-one | HCID 4623269 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
反応手順
8-Chloro-2-tetralone (500 mg, 2.78 mMol) in toluene (25 mL) was reacted with propylamine (1.14 mL, 13.9 mMol) and sodium borohydride (500 rag) as described in Example2 to give after purification by flash chromatography (5% methanol in dichloromethane+tr. NH4OH) the title compound as a dark oil (340 mg, 55%). The hydrochloride was formed, and recrystallization (ethanol/diethyl ether) gave a colorless, crystalline solid (m.p.=213°-215° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389687 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-9d681bdd390848d68b15aa5fbf35ee22 |
| 出典メモ | uspto-grants-1995_02 |